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Yohimbine HCL


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Yohimbine HCL Powder

Yohimbine HCL
CAS Number 146-48-5
Molar Mass 354.44 g/mol
Chemical Formula C21H26N2O3
IUPAC Name 17α-hydroxyyohimban-16α-carboxylic acid methyl ester


Yohimbine HCL, a chemical compound derived from the bark of the Pausinystalia yohimbe tree, is a research substance gaining attention for its potential applications in various scientific fields. While its traditional use has been associated with traditional medicine, its research potential is primarily centered around its impact on weight loss, and memory, and its potential implications for diabetes research.

Key Characteristics

Yohimbine HCL is characterized by its adrenergic antagonist properties, particularly its ability to block alpha-2 adrenergic receptors. This characteristic has led to investigations into its effects on metabolic processes, cognitive function, and potential benefits for diabetes-related studies.

Research Applications

Researchers are actively exploring the applications of Yohimbine HCL in various domains. From its potential role in weight loss interventions to its impact on cognitive processes, Yohimbine HCL is a subject of interest for those delving into the intricacies of adrenergic receptor modulation.

Research Benefits

Yohimbine HCL and Weight Loss

Studies have suggested that Yohimbine HCL may have a role in promoting weight loss by influencing the activity of adrenergic receptors, leading to increased lipolysis and energy expenditure. Researchers are delving into its mechanisms and potential applications in weight management.

Yohimbine HCL and Memory

Preliminary research has explored the effects of Yohimbine HCL on cognitive processes, including memory. Investigations aim to uncover whether its adrenergic modulation properties could have implications for cognitive enhancement.

Yohimbine HCL and Diabetes

Some studies have hinted at a potential link between Yohimbine HCL and improved insulin sensitivity. Research in this area is ongoing to understand the compound’s impact on glucose metabolism and its potential as an adjunct in diabetes-related studies.


Yohimbine HCL, with its adrenergic antagonist properties, is a compound under scrutiny for its potential benefits in weight management, cognitive function, and diabetes research. As researchers delve into its mechanisms and applications, Yohimbine HCL remains a focal point in various scientific investigations.


  1. Ostojic SM. Yohimbine: the effects on body composition and exercise performance in soccer players. Res Sports Med. 2006 Oct-Dec;14(4):289-99. doi: 10.1080/15438620600987106. PMID: 17214405. [Read More].
  2. O’Carroll RE, Drysdale E, Cahill L, Shajahan P, Ebmeier KP. Stimulation of the noradrenergic system enhances and blockade reduces memory for emotional material in man. Psychol Med. 1999 Sep;29(5):1083-8. doi: 10.1017/s0033291799008703. PMID: 10576300. [Read More].
  3. Sandberg M, Pettersson U, Henriksnäs J, Jansson L. The α2-adrenoceptor antagonist yohimbine normalizes increased islet blood flow in GK rats: a model of type 2 diabetes. Horm Metab Res. 2013 Mar;45(3):252-4. doi: 10.1055/s-0032-1323843. Epub 2012 Sep 26. PMID: 23015611. [Read More].


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