NSI 189 Phosphate


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NSI 189 Phosphate Powder

NSI 189 Phosphate
CAS Number 1270138-40-3
Molar Mass 366.509 g·mol−1
Chemical Formula C22H30N4O
IUPAC Name (4-Benzylpiperazin-1-yl)-[2-(3-methylbutylamino)pyridin-3-yl]methanone


NSI 189 Phosphate is a meticulously developed research product explicitly crafted for scientific exploration, emphasizing its application in research and refraining from any mention of human consumption. This compound serves as a valuable tool for researchers investigating its unique properties and potential benefits in various research domains.

Key Characteristics

NSI 189 Phosphate is a derivative of benzylpiperazine and has been of interest in the scientific community for its potential neuroregenerative properties. Recognized for its impact on neurogenesis, it has become a focus of research in the field of neuroscience.

Research Applications

NSI 189 Phosphate finds diverse applications in research domains, offering researchers a tool to explore its potential benefits. Its applications extend to investigations into major depressive disorder (MDD), ischemic stroke, and diabetic neuropathy.

Research Benefits

NSI 189 Phosphate and Major Depressive Disorder (MDD)

Studies suggest that NSI 189 Phosphate may have potential applications in addressing major depressive disorder. Research in this domain aims to understand its mechanisms of action and potential therapeutic applications in the context of depressive disorders.

NSI 189 Phosphate and Ischemic Stroke

Preliminary research indicates that NSI 189 Phosphate may have neuroprotective effects, particularly in the context of ischemic stroke. Investigations into its effects on neuronal survival and recovery contribute to understanding its potential applications in stroke-related conditions.

NSI 189 Phosphate and Diabetic Neuropathy

Research suggests that NSI 189 Phosphate may have implications for diabetic neuropathy, potentially influencing nerve function and regeneration. Studies exploring its effects on diabetic neuropathy-related parameters contribute to understanding its potential applications in neuropathic conditions.


NSI 189 Phosphate, developed exclusively for research purposes, provides researchers with a unique avenue for investigating its potential benefits in major depressive disorder, ischemic stroke, and diabetic neuropathy. The distinctive characteristics of NSI 189 Phosphate make it a promising subject for further exploration in neuroscientific and neuropsychiatric research.


  1. Fava M, Johe K, Ereshefsky L, Gertsik LG, English BA, Bilello JA, Thurmond LM, Johnstone J, Dickerson BC, Makris N, Hoeppner BB, Flynn M, Mischoulon D, Kinrys G, Freeman MP. A Phase 1B, randomized, double blind, placebo controlled, multiple-dose escalation study of NSI-189 phosphate, a neurogenic compound, in depressed patients. Mol Psychiatry. 2016 Oct;21(10):1372-80. doi: 10.1038/mp.2015.178. Epub 2015 Dec 8. Erratum in: Mol Psychiatry. 2016 Oct;21(10):1483-4. PMID: 26643541; PMCID: PMC5030464. [Read More].
  2. Tajiri, NQuach, DMKaneko, Y, et al. NSI-189, a small molecule with neurogenic properties, exerts behavioral, and neurostructural benefits in stroke ratsJ Cell Physiol2017232: 27312740. https://doi.org/10.1002/jcp.25847. [Read More].
  3. Jolivalt CG, Marquez A, Quach D, Navarro Diaz MC, Anaya C, Kifle B, Muttalib N, Sanchez G, Guernsey L, Hefferan M, Smith DR, Fernyhough P, Johe K, Calcutt NA. Amelioration of Both Central and Peripheral Neuropathy in Mouse Models of Type 1 and Type 2 Diabetes by the Neurogenic Molecule NSI-189. Diabetes. 2019 Nov;68(11):2143-2154. doi: 10.2337/db19-0271. Epub 2019 Sep 6. PMID: 31492662; PMCID: PMC6804627. [Read More].


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