NSI-189 Freebase


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NSI-189 Freebase Liquid

NSI-189 Freebase
CAS Number 1270138-40-3
Molar Mass 366.509 g·mol−1
Chemical Formula C22H30N4O
IUPAC Name (4-Benzylpiperazin-1-yl)-[2-(3-methylbutylamino)pyridin-3-yl]methanone


NSI-189 Freebase is a meticulously formulated research product designed explicitly for scientific exploration, with a strict exclusion of any mention of human consumption. This freebase form of NSI-189 serves as a valuable tool for researchers delving into its unique properties and potential benefits across various research domains.

Key Characteristics

NSI-189 Freebase is a derivative of benzylpiperazine, known for its potential impact on neuroregeneration and cognitive function. As a member of the nootropic class, it has become a focus of research due to its potential pro-cognitive effects.

Research Applications

NSI-189 Freebase finds versatile applications in research domains, offering researchers a tool to explore its potential benefits. Its applications extend to investigations into major depressive disorder, pro-cognitive efficacy, and its potential role in stroke recovery.

Research Benefits

NSI-189 Freebase and Major Depressive Disorder

Studies suggest that NSI-189 Freebase may have potential applications in addressing major depressive disorder (MDD). Research in this domain aims to understand its mechanisms of action and potential therapeutic applications in the context of depressive disorders.

NSI-189 Freebase and Pro Cognitive Efficacy

Preliminary research indicates that NSI-189 Freebase may have pro-cognitive effects, potentially influencing memory and cognitive function. Investigations into its impact on cognitive enhancement contribute to understanding its potential applications in supporting cognitive processes.

NSI-189 Freebase and Stroke

Research suggests that NSI-189 Freebase may have implications for stroke recovery, potentially influencing neuroregeneration and functional recovery post-stroke. Studies exploring its effects on stroke-related conditions contribute to understanding its potential applications in neurorehabilitation.


NSI-189 Freebase, developed exclusively for research purposes, provides researchers with a unique avenue for investigating its potential benefits in major depressive disorder, pro-cognitive efficacy, and stroke recovery. The distinctive characteristics of NSI-189 Freebase make it a promising subject for further exploration in neuroscientific and neuropsychiatric research.


  1. Fava M, Johe K, Ereshefsky L, Gertsik LG, English BA, Bilello JA, Thurmond LM, Johnstone J, Dickerson BC, Makris N, Hoeppner BB, Flynn M, Mischoulon D, Kinrys G, Freeman MP. A Phase 1B, randomized, double blind, placebo controlled, multiple-dose escalation study of NSI-189 phosphate, a neurogenic compound, in depressed patients. Mol Psychiatry. 2016 Oct;21(10):1372-80. doi: 10.1038/mp.2015.178. Epub 2015 Dec 8. Erratum in: Mol Psychiatry. 2016 Oct;21(10):1483-4. PMID: 26643541; PMCID: PMC5030464. [Read More].
  2. McIntyre RS, Johe K, Rong C, Lee Y. The neurogenic compound, NSI-189 phosphate: a novel multi-domain treatment capable of pro-cognitive and antidepressant effects. Expert Opin Investig Drugs. 2017 Jun;26(6):767-770. doi: 10.1080/13543784.2017.1324847. Epub 2017 May 8. PMID: 28460574. [Read More].
  3. Tajiri N, Quach DM, Kaneko Y, Wu S, Lee D, Lam T, Hayama KL, Hazel TG, Johe K, Wu MC, Borlongan CV. NSI-189, a small molecule with neurogenic properties, exerts behavioral, and neurostructural benefits in stroke rats. J Cell Physiol. 2017 Oct;232(10):2731-2740. doi: 10.1002/jcp.25847. Epub 2017 Apr 25. PMID: 28181668; PMCID: PMC5518191. [Read More].


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