N-Acetyl Semax Amidate


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N-Acetyl Semax Amidate Vails

CAS Number 4037-01-8
Molar Mass 813.93 g·mol−1
Chemical Formula C37H51N9O10S
IUPAC Name (2S)-1-[2-{[(2S)-1-[(2S)-2-{[2-{[(2S)-2-{[(2S)-2-amino-4-methylsulfanylbutanoyl]amino}-4-carboxybutanoyl]amino}-3-(1H-imidazol-5-yl)propanoyl]amino}-3-phenylpropanoyl]pyrrolidine-2-carbonyl]amino}acetyl]pyrrolidine-2-carboxylic acid


N-Acetyl Semax Amidate is a synthetic peptide derivative designed for research purposes only. It is a modified version of Semax, a nootropic peptide originally developed for cognitive enhancement and neuroprotective properties. This advanced formulation, N-Acetyl Semax Amidate, aims to explore potential applications in various research areas.

Key Characteristics

N-Acetyl Semax Amidate is a modified peptide with an amidated structure for enhanced stability. Designed to interact with neural receptors, particularly those associated with dopamine regulation and cognitive function.

Research Applications

N-Acetyl Semax Amidate is intended for investigation into its effects on neurotransmitter pathways, specifically dopamine regulation. Additionally,   it is also used to nvestigate its potential applications in addressing cognitive disorders and attention-related conditions.

Research Benefits

Semax and Dopamine

Research suggests that Semax may modulate dopamine levels in the brain, influencing mood, motivation, and cognitive processes.

Semax and ADHD

Preliminary studies indicate that Semax might exhibit properties beneficial for individuals with attention deficit hyperactivity disorder (ADHD).

Semax and Memory

Ongoing research explores the potential of Semax in enhancing memory and cognitive functions.


N-Acetyl Semax Amidate is a research peptide with modified characteristics aimed at investigating its neuroactive properties. While research is ongoing, potential benefits include the modulation of dopamine, implications for ADHD, and cognitive enhancement.


  1. Eremin KO, Kudrin VS, Saransaari P, Oja SS, Grivennikov IA, Myasoedov NF, Rayevsky KS. Semax, an ACTH(4-10) analogue with nootropic properties, activates dopaminergic and serotoninergic brain systems in rodents. Neurochem Res. 2005 Dec;30(12):1493-500. doi: 10.1007/s11064-005-8826-8. PMID: 16362768. [Read More].
  2. Shih-Jen Tsai, Semax, an analogue of adrenocorticotropin (4–10), is a potential agent for the treatment of attention-deficit hyperactivity disorder and Rett syndrome, Medical Hypotheses, Volume 68, Issue 5, 2007, Pages 1144-1146, ISSN 0306-9877, https://doi.org/10.1016/j.mehy.2006.07.017. [Read More].
  3. Asmarin IP, Nezavibat’ko VN, Miasoedov NF, Kamenskiĭ AA, Grivennikov IA, Ponomareva-Stepnaia MA, Andreeva LA, Kaplan AIa, Koshelev VB, Riasina TV. Nootropnyĭ analog adrenokortikotropina 4-10-semaks (15-letniĭ opyt razrabotki i izucheniia) [A nootropic adrenocorticotropin analog 4-10-semax (l5 years experience in its design and study)]. Zh Vyssh Nerv Deiat Im I P Pavlova. 1997 Mar-Apr;47(2):420-30. Russian. PMID: 9173745. [Read More].


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